Laparoscopy is the technique of using the "pneumoperitoneum" process to 

extend and examine the abdominal cavity using CO2. Laparoscopic and other 

procedures produce pain, which varies in intensity, duration, and type. 

Crystalloid fluid types, for instance, Normal saline (NS) and Ringer's lactate 

(RL) solution, aid in reducing laparoscopic pain. Therefore, the research 

explores intraperitoneal crystalloid solutions in reducing post-laparoscopic 

surgery shoulder pain. The research adopted a prospective, single-blind study 

based on a single-center, randomized, and parallel research design. A total of 

80 diagnosed patients (40 subjects in each arm) with laparoscopic surgery 

were randomly recruited at Zintan Medical Center, Alzintan, Libya. Patients 

were equally divided into Group A (crystalloid solutions) and Group B (routine 

measures) and were assessed through self-administered pain scores. 

Through the numeric rating scale (NRS), the research findings revealed 

significant pain intensity differences between Groups A and B at 6, 12, 24, 

48, and 72 hours. In contrast, no significant difference in pain was observed 

between groups A and B on the fourth and fifth days. Additionally, lower pain 

intensity was observed in group A than in group B; at 6 hours, the mean pain 

score for group A and B measured 2.55 and 6.40 at 6 hours, respectively. The 

intraperitoneal crystalloid solutions infusion aids in reducing pain severity 

among laparoscopic surgery patients. Future research should address 

extended follow-up periods to determine the effects of NS and RL 

interventions. Moreover, stakeholders should implement Ringer's lactate 

solution (RL) to reduce post-laparoscopic complications

Background: Gastrointestinal stromal tumors (GISTs) are the major mesenchymal tumors of the gastrointestinal 

tract (GIT), which progress due to the mutation in TKI and PDGFR-α receptors. It shows asymptomatic conditions 

however, become malignant due its large size and produce abdominal pain. Several surgical managements have 

been applied to diagnose patients with GIST, but these increase the risk of tumor recurrent rate. Therefore, 

adjuvant therapies contribute to preventing this challenge with several side effects and post-operative 

complications. A 42-year-old male patient from Libya with acute abdomen and GIST in small bowel (Jejunum) 

was diagnosed with complete excision besides lymph node dissection..Aim: To investigate numerous case reports 

through literature analysis regarding GIST along with a case presentation of the patient. Method: This research 

employed a literature-based study design. Previous case reports were screened from various online research 

platforms, including the National Center for Biotechnology Information (NCBI) and PubMed. A total of 37 cases 

were included through the search phrase "Case report on Gastrointestinal stromal tumor” .. Results: The findings 

revealed patient mean age (56.35) with most of the small intestine GIST (6.42 cm) site of origin, antibodies 

expression, and maximum mitotic cell counts.. Conclusion: The cases reported a risk of recurrence among GIST 

patients due to high mitotic counts and tumor size. Future researchers should address immune markers to reduce 

tumor recurrence among GIST patients. Stakeholders should implement proper treatment procedures with 

effective diagnostic methods. 

Keywords: Gastro-Intestinal Stromal Tumors (GISTs), Perforation, Imatinib, Acute abdomen, Tyrosine Kinase 

Inhibitor (TKI), Small Bowe